I have reacted to my husband and kids after they washed their hands with soap contain this chemical. He RJ, Li J, Huang YL, Wang YF, Yang BY, Liu ZB, Ge L, Yang KD, Li DP. This site uses Akismet to reduce spam. In my tooth paste.. CAS NO. Hope you start your list Colin! The long-term consequences of low-level chronic exposure to isothiazolinones on the CNS have not been investigated.Which literally means they know enough to say it wont be good news. Pingback: Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) Free Dandruff Shampoos | Dandruff Deconstructed. Both the components are highly water soluble, and have hardly any potential to penetrate the skin or to build up in the … Are you kidding me? The nasty thing with cosmetics is, you don’t always get the wrapping with it, so the ingredients are more difficult to trace. Which doesnt mean its safe or passed it means they havn’t screened it yet. This, in turn, can facilitate the codelivery of immunopotentiators, also known as adjuvants, which is important to enhance vaccine efficacy [ 66 , 67 ]. How much havoc did it cause me? It did no such thing and is being linked to neurological damage cell death, the kind that causes defects and cancer. None of my cosmetic products contain the methy stuff – but since the paint does, it could easily be singled out as the main offender. At high concentrations they are quite bad skin irritants. ), Isothiazolinones: (methylisothiazolinone and methylchloroisothiazolinone). Message I have received a message from Ecover that all their products are MI/MCI free except Stain Remover, Non Biological Laundry Gel and Bio Laundry Gel. Found inside – Page 4031... 2226–2228, 2227f, 2228t vitamins fat-soluble, 2204–2211, 2204b, 2280 water-soluble, 2211–2221 Micronychia, ... 3236, 3236t Methylchloroisothiazolinone/ methylisothiazolinone (MCI/MI), allergic contact dermatitis from, ... Figure 1. Methylisothiazolinone, is a … If this is possible, what concentration can be used ? Do VQ, Seo YS, Park JM, Yu J, Duong MTH, Nakai J, Kim SK, Ahn HC, Lee MY. Incidentally Simple tend to use the parabens as their preservative of choice from what I can see. Thanks for that link Beth. Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. All these products are fragrance free and preservative free. Methylisothiazolinone is an efficient broad-spectrum fungicide that prevents the growth of gram-positive bacteria and gram-negative bacteria. MIT is a clear, colourless liquid that is soluble in water. It is more that I am now sensitized. Sorry to hear that patch test result Tracy. Hopefully we have shed some light on a few ingredients that get confused with silicones from time to time and helped you understand the differences between them and silicones and (more importantly) whether they are okay for you to use with your particular hair routine. Around 15ppm is just about the maximum that is ever used and it often does well at much lower levels. Like Lesley above, is there a list of products free from this, it would be much easier to consult this than try and find out product by product, which is not easy. Water is also a fundamental growth factor for most microorganisms, with most needing a water activity above 0.50 for growth. I have never had the slightest problem with pH or oil levels. Perfect for shelf life maybe but certainly not anything that lives. however, I do check everytime because I have found that manufacturers change ingredients quite often. Thanks for your contribution and hopefully I have put your mind at rest. After 6 years of high potency steroids for a rare hand scalp and lip eczema. My story is not uncommon and I am learning that the number of people allergic to MI/MCI is growing. including a link for the many class action suits against companies claiming this chemical is safe and natural But once something gets a bad name it is a devil of a job to shift it. Int J Toxicol. I know I have to do a controlled study of not using Methylisothiazolinone for a while before I get reviewed again, but you should have seen the angry mess on my back, exactly where the Methylisothiazolinone was. It's a very common tissue fixative agent, and could be added to inks for its microbial properties. The only issue of concern was sensitisation, which was considered as not an issue in rinse off products. If a product isn’t labelled with methylchloroisothiazolinone and methylisothiazolinone then it shouldn’t contain them. If you have read Silent Spring, or my review of it, you’ll be well aware that accumulation in tissues can  have unpredictable and undesirable consequences. In the 90’s the number of those sensitized to MI/MCI remained steady and in some countries even decreased. M. D. Lundov1, J. D. There are a number of acronyms used, but my favourite coping strategy is used by the owner of a small personal care company who simply refers to the combination as ‘methy whatsits’. I am tossing out most of the soaps, lotions, sun screens etc. I must conclude that it seems no-one has enough data to make a definitive statement on this topic. This is the least sensitising of the two and so this might be a chance to re-evaluate it. where can I find out ALL the products this horrible product is in???? I hope so. Should I be concerned about how they may affect my hair if I am avoiding strong surfactants (sulfates) in my hair care routine? Shame on you, little of what you posted was even marginally close to true or fact. These are exceptions that are OK: (The raw ingredients dissolve in water and rinse off with plain water.Shampoo may or may not be necessary to remove products containing these ingredients). After hearing the results of my week without bath, I check through the list of products and ingredients I supplied to my dermatologist and find that the only one with Methylisothiazolinone is my hair conditioner. The lack of general understanding of the difference between hazard classification and risk assessment leads to opinions of the sort you refer to. This name is easily confused with the very similar notation used for many silicones: polydimthylsiloxane. Found insideOne must be watersoluble to protect the watery part of the shampoo, and the other oilsoluble to preserve the oils in the emulsion. The paraben family, formaldehyde, glyoxal and the methylchloroisothiazolinone/methylisothiazolinone ... But maybe I am too pessimistic and this will give us a new option. A water-soluble, chemical sunscreen agent that is a secondary UVB absorber with some activity in the short UVA range as well. The list goes on, but I am sure you get the point. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Biggest problem i have is not knowing or being able to find the ingredients listed and there are so many names for it. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble. Coolants are formulated to control heat in the cut and flush chips from the cutting zone. However, they also told me that it’s possible to neutralize the methy whatsits with a solution of sodium thiosulfate pentahydrate, which needs to be applied to all surfaces covered with the paint. After reading your post I conclude that the amounts used as an ingredient are most probably harmless but I’d still like to know more. The bigger take-away message is that many of the ingredients listed on cosmetic packages can be strikingly similar and certainly confusing! Int J Toxicol. Highlighted Ingredients: - Mandelic Acid: Derived from almonds, mandelic acid is an AHA (alpha hydroxy acid) that is both water and lipid soluble, which is a quality that allows it to penetrate and work within the hair follicle. Previously I’ve thought all liquid soaps (not really soaps, but that’s what they’re called) had to be irritating (drying actually, but dryness irritates). 2007;26 Suppl 3:1-30. doi: 10.1080/10915810701663143. https://www.jneurosci.org/content/22/17/7408?fbclid=IwAR3lnXkrHuL6cfeqksvZ77L8FMFa2e0TtCTPZXwgfASkWP6pkZwkXm1vdP0. What it is: A cream deodorant that soothes underarm skin, keeps odor at bay, and is free of baking soda, essential oils, and aluminum-derived ingredients. Consistent with its solubility, dermal penetration is low. Although their practice is completely legal, and this may make people sleep easier at night, the moral implications for me on a personal level are massive. Again another dubious claim since I just read about 8 marketing tricks and selling tactics in this article. Because of their widespread use, the neurotoxic consequences of both acute and chronic human exposure to these toxins need to be evaluated. MIT-50 is an active ingredient solution for the preservation of paints, binder dispersions, adhesives and other technical products.MIT-50 is a straight aqueous solution of the active ingredient Methylisothiazolone, and does not contribute to VOC and AOX. Arch Toxicol. Someone asked about laundry liquid and makeup (okay he doesn’t wear makeup but I’m trying to clear everything in the household for him). I also found out the contact dermatitis is down to these products too!!!!! Chloromethyl-methylisothiazolone is a broad spectrum fungicide which prevents the growth of bacteria, fungi and algae, and especially has been used successfully for microbial control and preventing biofouling in water treatment application. I’m so pleased I’ve stumbled upon this website, I shall continue to check for updates on what I can and cannot use. Some products do not list this as an ingredient, but my skin tells me that it’s there. Product Name: Methylisothiazolinone. Found inside – Page 84mixture of methylchloroisothiazolinone and methylisothiazolinone 55965-84-9 2.2 EINECS No : None 2.3 Molecular ... ( 20 ° C ) ( 2 ) 3.6 Solubility : Kathon WTE : freely soluble in water Kathon CG : Miscible with water , lower alcohols and ... I think it is impossible to dismiss the fact that it is a sensitiser, but it is easy to exaggerate just how bad it is. The next one (some LE summer or winter scent) didn’t. Found inside – Page 49Water, demineralized 30.0 43.25 36.5 48.5 18b. ... Methylchloroisothiazolinone (and) Methylisothiazolinone - 22. ... 767 (Dynamit Nobel); (14) Water-soluble Vegetol Marigold (Gattefossé/Alfa Chemicals); (15) Extrapone Chamomile Shower ... They have also been extensively tested for potential carcinogenicity, and have passed with flying colours. Hence why i am allergic. Cutting metal is a complex process involving many critical factors to be successful. These lists come from databases and your doctor should be giving you one as part of treatment. 1.13%) / Methylisothiazolinone (MIT, approx. Methylchloroisothiazolinone/Methylisothiazolinone (aka Kathon CG), http://www.goodguide.com/ingredients/258653-methylchloroisothiazolinone, http://ijt.sagepub.com/content/29/4_suppl/187S.abstract, http://www.satra.co.uk/spotlight/article_view.php?id=290, http://www.fdaaa.org/fdaaa_leadership/aAndersen.php, http://personalcaretruth.com/2011/08/the-cosmetic-ingredient-review-and-safe-cosmetics/, http://orlandoskindoc.com/Contact%20Dermatitis%20Forms/test.methycloroisothiazolinone.htm, https://books.google.com/books?id=sSHIlWSOiroC&pg=PA564&lpg=PA564&dq=methylisothiazolinone+other+names&source=bl&ots=lgEQQRt-Hc&sig=eqRpTH6SGEH72ubm-2VDSXJ_y0E&hl=en&sa=X&ei=2Bk2VZTAO7XIsASx6YHQDw&ved=0CCAQ6AEwAjgU#v=onepage&q=methylisothiazolinone%20other%20names&f=false, Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) Free Dandruff Shampoos | Dandruff Deconstructed, https://www.jneurosci.org/content/22/17/7408?fbclid=IwAR3lnXkrHuL6cfeqksvZ77L8FMFa2e0TtCTPZXwgfASkWP6pkZwkXm1vdP0, https://www.occderm.asn.au/health-professionals/epidemic-of-allergy-to-preservative-methylisothiazolinone-mi/, https://classactionsreporter.com/green-works-natural-cleaning-products-deceptive-advertising-class-action/. It has been very helpful. These molecules are used in a wide variety of products, typically for their superior conditioning effects and their ability to impart gloss and shine. Well written and thought out, a very balanced and un-bias article and I appreciate the personal level of the conclusion…an honest opinion is always refreshing. And saying it doesnt absorb through the skin is sheer lunacy, what do you think lotion does, or make up ? This is probably the best option for minimising skin reactions overall, but it obviously won’t suit everybody. Hi there! Add cosmetic liquid color dye as desired. My daughter is alergic to Kathon cg or methy and on a recent trip to Turkey her eyes came up like golf balls, tracked it down to the biocide in the swiming pool full uf the stuff so take care. Of course, as I am sure you realise, using a combination of preservatives mean there are more names on the ingredient list which makes you even more vulnerable to scare stories. It is widely recognized as a perverse allergen and irritant, and was named the contact allergen of the year a few years after you posted this! Awareness of this chemical preservative has risen and more and more people are being tested and coming up with a positive allergy to it. But most of the time you can trust the ingredient list. It is a shame because this irritancy really isn’t a problem so long as you keep the concentration low enough. So far the Castille style “soaps” have proved clear, and so has the “Ecover” brand of household products. Preservation using combinations of preservatives has several advantages. Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. actually it is not easy and almost impossible to find skincare product that do not contain this preservative. CMIT/MIT is the most suitable biocide in industrial circulating cool water systems and in wastewater treatment for oilfield, papermaking, pesticide and other industries. It is not always listed on the bottle, or on the ingredients list and is often included in many companies’ “proprietary formula”. Formaldehyde is soluble in water (as the hydrate), you can purchase it as a 37% aqueous solution. Does anybody know whether maybelline foundation has an ingrediant as known as ‘methylchloroisothiazolinone’ in it , its covered with that name when actually its ‘bleach’. They are also readily biodegradable. I am hoping to be proved wrong and someone knows an easier way to find them. I was diagnosed earlier this year with contact dermatitis and then I used asda little angles baby wipes on my face they must have changed their formula and my face broke out terribly I went back to hospital and got patch tested last week and found out im allergic to methylchloroisothiazolinone/methylisothiazolinone(kathlon CG) so far I have detected it is contained in anti bacterial products in a high dose found it in fairy liquid and handwash. It is of course the case with cosmetic products that the preservatives will be included with the other ingredients on the ingredient list. I didn’t realise it was used in laundry products. Methylisothiazolinone, is a powerful general biocide and preservative within the group of isothiazolinones, often used in personal care products. This ingredient is meant to bind to hair (specifically to damaged areas), it may build up or accumulate to weigh down especially build-up prone hair or lightweight hair types or it may . Was told by dermatologists to use no cosmetics, no perfumes, and no fragrant candles. But they do have some perverse effects as well. Found inside – Page 290Many watersoluble polymers are derivatives of cellulose. The cellulosic polymers possess an anionic or nonionic charge and numerous grades with various properties are commercially available. The commercial grades vary in molecular ... Preserving a swimming pool with Kathon CG? Cold Processed soap doesn’t contain preservatives and natural liquid soap (made with lye not from surfactants) doesn’t either. Pure water is not found in nature due to the solvent capabilities of the non-polar water molecule. I am convinced that I am allergic to methylchloroisothiazolinon . I have rewashed all clothing and fabrics I come in contact with. MIT is a … Now I’ve put that out there I hope you’ll join me in trying to make that the standard term for this preservative combination. It is indeed difficult to avoid the stuff. Methylchloroisothiazolinone, also referred to as MCI, is the organic compound with the formula S(C 2 HCl)C(O)N(CH 3).It is a white solid that melts near room … Whenever I need to preserve something in the lab – which is quite often, bugs are everywhere – it is my first choice. I haven’t heard that one before. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.01%) or less would not be expected to pose a sensitization risk. I have taken to emailing companies and asking them. No combination of preservatives showed any inhibitory action on each other. Methylisothiazolinone (MIT) is a common preservative used in the home and personal care industry, however there are concerns it can cause skin allergies in some people. I could no longer hold my child hands they were constantly wrapped.. Two weeks after removing it from my care products it cleared no steroids needed. I am not saying that a ban should take place (everything has a purpose), but I strongly feel that ANY product containg ANY of the Isothiazolinones should have it listed ON THE LABEL. In my shampoos and conditioners the lotion my dermatologist recommended and in others I substituted for. Patches are now off, and the dreaded Methys “appear” to be my one downfall. Pure water has a water activity of 1.00. They don’t talk about the azonilones on their website but I haven’t found any listed on any of their packs yet. Tight coils and soft wavy tresses, African American curls and curly kids - this is what to do to look and feel your best. It is time consuming but there seems no other way. Found inside – Page 522... there are two preservatives — methylchloroisothiazolinone and methylisothiazolinone ( together they go by the trade ... 6.75 ounces ) isn't mild in the least , though it is a standard , detergent - based , water - soluble cleanser . Section 4- FIRST AID MEASURES Eye contact first aid: rinse for 15 min with water, if discomfort or irritation persists, contact a . You make issue about it being used in low level amounts making it safe. Methylisothiazolinone combination is in many ways an ideal preservative system but it does have an Achilles heal' 'chapter 4 an introduction to chemical reactions may 12th, 2018 - chapter 4 - an introduction to chemical reactions 39 compounds are soluble in water or not and 3 a description of the process for writing' They shouldn’t need preservation at all. I have reacted going in to someone’s home after they sprayed air freshener, because it contains this chemical. Would you like email updates of new search results? You claim you arent promoting this product or being paid by them. So who can you trust? Effects of Kathon, a Chemical Used Widely as a Microbicide, on the Survival of Two Species of Mosquitoes. Int J Toxicol. I use non bio detergent, I have cold water cleaning system – no chemicals just cloths, and I drink goat or soya milk, never cow. I had patch testing done this week and am allergic to Methylisothiazolinone. The more accurate ‘Kathon CG is a potent skin sensitiser at levels well above its normal use levels, but despite that it is still a good choice because it is so effective you can use it at really low levels so you get hardly any skin reactions in normal use’ doesn’t really trip off the tongue nearly as well. The combination works extremely well at astonishingly low levels. Arch Toxicol. 2021 Jul 9;26(14):4177. doi: 10.3390/molecules26144177. Agent orange – could we be talking about disperse dye orange – http://www.satra.co.uk/spotlight/article_view.php?id=290. I’m so paranoid of anything staring ‘Methyl’ or ending ‘Lione’, the last few months have been a living hell and I’m just desperate to do everything I can to make sure this problem doesn’t keep returning. Atwater AR, Petty AJ, Liu B, Green CL, Silverberg JI, DeKoven JG, Belsito DV, Reeder MJ, Sasseville D, Taylor JS, Maibach HI, Zirwas MJ, Marks JG, Zug KA, Fowler JF Jr, Pratt MD, DeLeo VA, Warshaw EM. Found inside... water soluble and compatible with most emulsions. The stability of Kathon 886 at various pH values is described by Croshaw [488]. Methylisothiazolinone alone as 9.5% in water (commercially available as Neolane M-10 (Rohm and Haas)) ... So your either ignorant or lying. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_009.pdf. This means that water and other ingredients don't go in or out of the hair strand easily, so using the wrong product didn't have a huge effect. Products containing methylisothiazolinone are added to systems and industrial products using manual pouring and metered pumping methods, dip tanks and sprayers. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration. This is a real tragedy, because in every other respect they really are the ideal preservative system. Orlane Creme Cover-up. But the trouble is it is still going to look bad when tested at a high level in a patch test. If you have the time, it would be very public spirited to notify the manufacturer of your experience. Sorry, your blog cannot share posts by email. My original visit to the web was merely to research food that my G6PD deficient son should avoid. Isododecane can be used as s solvent for higher molecular weight water insoluble components such as silicones. Again thank you for your very interesting artical. Please enable it to take advantage of the complete set of features! I am allergic to Caine products so thats tricky on sunburn. Healthy hair should be soft, full, solid, and shiny. This site needs JavaScript to work properly. DMDM hydantoin, as I learned from patch testing after admission to hospital for anaphylactic shock. Alternatively after 7 searches on the web in varying ways no information come up with anything for them having been tested as a carcinogen. Hello, I found out that I’m allergic to nickel and kathon cg. I am a hairdresser and was only working 5 hours a week in contact with it. And it literally takes very brief exposure for it to illicit a reaction in me. Melting point is 114~116, Boiling point is 246. I asked if MI is “hidden” under fragrance / parfum. Hi interesting coments. Thanks in advance! You really DO know how to pick ’em! I think you should be fine with them. Avon produts appear to use this agent as well. Amended final report on the safety assessment of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate. If I have made any errors in my blog I am happy to be corrected. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Drs Jennifer Cahill and Rosemary Nixon, dermatologists with the Skin Health Institute (formerly the Skin and Cancer Foundation Inc) In 2011 “Our current rate of positive test reactions to MI to November 2013 is 11.3% (40 patients who had relevant reactions of a total 353), compared with a rate of 3.5% (15/428) in 2011 and 8.4% (38/454) in 2012”, Dr Cahill wrote.“MI is now the most common cause of allergic contact dermatitis in our patient population. Only last week I was tested and confirmed that it was methy whatsit that was causing all my problem and was so worried that I could not use any cosmetics again but I now have new hopes. I inform companies when I react. It's still a stinker to remove from hair and it does require a clarifying shampoo now and then to do so, but despite that, I still include it in my heat protecting hair care formula. The cell death process also involves activation of NADPH oxidase, generation of reactive oxygen species, DNA damage, and overactivation of poly(ADP-ribose) polymerase, all occurring downstream from ERK phosphorylation.
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