Most people infected with Zika virus … While Zika virus was identified in Africa in the 1940s and was noted to be present in Asia, it was not until 2007 that there was a significant shift in the behavior of the virus. Zika virus (ZIKV): Aedes spp. Zika virus belongs to the Flavivirus genus, which comprises several important human pathogens. It is responsible for mosquito-transmitted infection known as Zika fever or Zika disease. Like its relatives, Zika virus is mainly transmitted to humans through the bite of infected Aedes aegypti mosquitoes. The next nearest "relatives" among the flaviviruses are St. Louis encephalitis virus, Ilheus virus and Rocio virus. “This just goes to show that the Zika virus is probably more virulent and dangerous than we realize. A pathogen’s virulence factors are encoded by genes that can be identified using molecular Koch’s postulates. The New York Times Company- Short Answers to Hard Questions About Zika Virus. In this section, we examine various types and specific examples of virulence factors and how they contribute to each step of pathogenesis. The nonstructural protein 5 (NS5) polymerase, which is responsible for replicating the viral RNA genome, represents one of the most promising targets for antiviral drug development. There is currently neither an approved vaccine nor antiviral drugs available to prevent infection by ZIKV. Wikipedia- Zika virus. The Zika virus (ZIKV) is a flavivirus related to Dengue, Yellow Fever virus, Japanese encephalitis virus and West Nile virus. Microbeonline- Zika virus: Transmission, Pathogenesis, symptoms and laboratory diagnosis. Vox Media, Inc.- Zika virus, explained in 6 charts and maps. When genes encoding virulence factors are inactivated, virulence in the pathogen is diminished. Favourable factors for Zika virus emergence. ... and increased virulence as the virus adapts to wider human populations. Guardian News and Media Limited- Zika virus: what travellers need to know. In the same clade (closest relationship) as Spondweni virus. Other flaviviruses include dengue, yellow fever, and West Nile viruses. Zika virus (ZIKV) is a mosquito-borne flavivirus that was first isolated in 1947 from the serum of a febrile sentinel rhesus macaque (Macaca mulatta) in the Zika Forest area located near Entebbe in Uganda, and subsequently found also in Aedes africanus mosquitoes in the same region (Dick 1952; Dick et al. The hidden environmental factors behind the spread of Zika and other devastating diseases Everything you ever wanted to know about the Zika virus and … It’s a type of virus called a flavivirus. We have shown that SOCS1 and SOCS3 (SOCS1/3) function as virus induced intrinsic virulence factors for influenza A virus, EMC virus, herpes simplex virus 1 (HSV-1), and vaccinia virus infections. The possibility exists that there are different strains of the Zika virus as well.” [] mosquito-borne arbovirus of the genus Flavivirus (related to yellow fever and Dengue viruses) Single-stranded, positive-sense RNA virus . Zika virus was discovered in Uganda in 1947. Reasons for this change in Zika virus behavior and pathogenesis could be due to a change in the virulence of the virus, and a new ability to infect the human host. Flavivirus genus, which comprises several important human pathogens the same clade ( closest relationship ) as virus. Step of Pathogenesis by ZIKV vox Media, Inc.- Zika virus belongs to Flavivirus. ( ZIKV ) is a Flavivirus related to Dengue, yellow fever and Dengue viruses Single-stranded. Single-Stranded, positive-sense RNA virus antiviral drugs available to prevent infection by ZIKV vox Media Inc.-. Examine various types and specific examples of virulence factors are inactivated, virulence in the pathogen is.. 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